A new method for early screening and diagnosis of colorectal cancer can be developed by taking just a few milliliters of blood, according to the Chinese research team in Washington, DC, on January 4. The research is published in a new issue of the American Journal of Science and Transformational Medicine.
the team of professor xu ruihua of the cancer prevention and treatment center of zhongshan university collected circulating tumor dna extracted from 801 patients with colorectal cancer and 1021 patients with normal control, from which 9 methylation markers could be selected for diagnosis of colorectal cancer, and 5 methylation markers to predict the prognosis of colorectal cancer.
Circulating tumor DNA is a small fragment of the genome released by tumor cells into the circulatory system, a characteristic tumor biomarker, like a \"fingerprint\" left by tumor cells.
this study showed that the diagnostic model of colorectal cancer based on circulating tumor dna methylation markers was 96% accurate, compared with the current clinically commonly used serum marker cancer embryo antigen CEA with only 67% accuracy. In addition, the accuracy of the new prognostic model for patient survival prediction is also significantly higher than the commonly used prognostic indicators, which means that doctors can carry out more individualized and accurate treatment for different colorectal cancer patients. The researchers also performed simultaneous colonoscopy screening and detection of circulating tumor DNA methylation markers in a high-risk population of 1,493 colorectal cancer. The results showed that the sensitivity of the latter to detect early bowel cancer was as high as%, and the sensitivity to detect advanced adenomas (precancerous lesions) also reached%, and it had better patient compliance, which provided a new noninvasive method for early screening of colorectal cancer.
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