据新华社华盛顿1月4日电(记者周舟)中国研究团队研发出一种只需抽取几毫升血液就可对结直肠癌进行早期筛查和诊断的新方法。该研究成果发表在新一期美国《科学·转化医学》杂志上。

A new method for early screening and diagnosis of colorectal cancer can be developed by taking just a few milliliters of blood, according to the Chinese research team in Washington, DC, on January 4. The research is published in a new issue of the American Journal of Science and Transformational Medicine.

  中山大学肿瘤防治中心徐瑞华教授团队收集了801例结直肠癌患者和1021例正常对照者血浆提取的循环肿瘤DNA,从中筛选出9个可用于诊断结直肠癌的甲基化标志物,以及5个预测结直肠癌预后的甲基化标志物。

the team of professor xu ruihua of the cancer prevention and treatment center of zhongshan university collected circulating tumor dna extracted from 801 patients with colorectal cancer and 1021 patients with normal control, from which 9 methylation markers could be selected for diagnosis of colorectal cancer, and 5 methylation markers to predict the prognosis of colorectal cancer.

  循环肿瘤DNA是肿瘤细胞释放到循环系统中的基因组小片段,是一种特征性的肿瘤生物标记物,就像是肿瘤细胞留下的“指纹”。

Circulating tumor DNA is a small fragment of the genome released by tumor cells into the circulatory system, a characteristic tumor biomarker, like a \"fingerprint\" left by tumor cells.

  这项研究显示,基于循环肿瘤DNA甲基化标志物的结直肠癌诊断模型的准确率达到96%,而目前临床常用的结直肠癌血清标志物癌胚抗原CEA的准确率只有67%。另外,新的预后模型对患者生存预测的准确性也明显高于目前临床常用的预后指标,这意味着医生可以据此对不同的结直肠癌患者进行更为个体化的精准治疗。研究人员还对1493例结直肠癌高危人群同时进行了肠镜筛查和循环肿瘤DNA甲基化标志物的检测。结果显示,后者检出早期肠癌的敏感性高达%,对进展期腺瘤(癌前病变)的检出敏感性也达到%,且具有更好的患者依从性,为结直肠癌的早期筛查提供了新的无创性方法。

this study showed that the diagnostic model of colorectal cancer based on circulating tumor dna methylation markers was 96% accurate, compared with the current clinically commonly used serum marker cancer embryo antigen CEA with only 67% accuracy. In addition, the accuracy of the new prognostic model for patient survival prediction is also significantly higher than the commonly used prognostic indicators, which means that doctors can carry out more individualized and accurate treatment for different colorectal cancer patients. The researchers also performed simultaneous colonoscopy screening and detection of circulating tumor DNA methylation markers in a high-risk population of 1,493 colorectal cancer. The results showed that the sensitivity of the latter to detect early bowel cancer was as high as%, and the sensitivity to detect advanced adenomas (precancerous lesions) also reached%, and it had better patient compliance, which provided a new noninvasive method for early screening of colorectal cancer.

看高血压是咋一步步弄坏心脏的5种方法降血压动脉血管内压力过高,心脏排血的阻力就会增大,久而久之会逐渐引起心室壁肥厚。之后,其运动会变的呆滞、不灵活、不协调,对心脏泵血功能造成影响,严重时可因心脏舒张能力变差导致心衰。

See hypertension is how step by step damage to the heart of the five ways to lower blood pressure arterial pressure is too high, the resistance to cardiac blood excretion will increase, over time will gradually cause hypertrophy of the ventricular wall. Later, its exercise will become dull, inflexible, uncoordinated, to the heart pump blood function, severe may be due to the heart diastolic ability to lead to heart failure.

止打嗝、防老花、解腰痛这些小窍门有大用掐攒竹止打嗝。攒竹穴在面部,眉毛内侧眉头凹陷处。取坐位,双手放于桌上,双手拇指食指指尖立起,低头闭目,用力掐攒竹穴,由于指尖受力面小,局部很容易就会有酸胀感。每次坚持10秒钟,可轻轻放松一下,反复掐至少5次。

Stop hiccups, prevent old age, relieve waist pain these tips have big use to save bamboo to stop hiccups. Zanzhu point in the face, eyebrow inside the brow depression. Take the sitting position, hands on the table, hands thumb food finger pointed up, bow closed eyes, hard to save bamboo hole, because the fingertips force small, local will easily have a feeling of acid expansion. Hold on for 10 seconds each time, can gently relax, repeatedly pinch at least 5 times.

冬季热水泡脚有4大好处,但这5类人需谨慎泡脚是中医的一种养生保健方法,具有加快血液循环、刺激穴位、解乏散寒之功效,同时还能提高人体免疫力,帮助抵御各种疾病。

Winter hot water foot bubble has four major benefits, but these five categories of people need to be careful foot bubble is a health care method of traditional Chinese medicine, with the ability to speed up blood circulation, stimulate acupoints, relieve cold, but also improve human immunity, help resist various diseases.


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